Abstract
Purpose: To determine the visual outcome of laser treatment and intra-vitreal
Avastin (Bevacizumab) injection as mono-therapy or combined, in patients with
Vision Threatening Diabetic Retinopathy (VTDR).
Study Design: Quasi Experimental study with non-probability convenient
sampling.
Place & Duration of Study: Isra Postgraduate Institute of Ophthalmology, AlIbrahim Eye Hospital, Karachi from January 2016 to December 2017.
Material & Methods: Patients with Diabetic retinopathy (DR) were graded
according to International clinical diabetic retinopathy & macular edema disease
severity scale. Patients with VTDR were offered Laser therapy, intra-vitreal
Avastin injection or both.
Results: VTDR was witnessed in 586 patients out of 1988 patients with DR. Out
of which 108 had Proliferative Diabetic Retinopathy (PDR), 382 had clinically
significant macular edema (CSME) and 96 had Advanced Diabetic Eye Disease
(ADED). Laser was done in 78 eyes, intravitreal Avastin was given in 340 eyes
and combined laser and Avastin were given in 35 eyes. When visual outcome
was correlated with treatment modalities, improvement was found in 248 eyes,
deterioration in 34 eyes and stabilization in 58 eyes of Avastin group, whereas
improvement was seen in 45 eyes, deterioration in 15 eyes and stabilization in
18 eyes of laser group. In combined treatment group, improvement was
witnessed in 23 eyes, deterioration in 4 eyes and stabilization in 8 eyes.
Conclusions: Visual outcome of Avastin alone or combined with laser was
found to be better than laser treatment alone in stabilizing the visual acuity in
patients with vision threatening diabetic retinopathy.
Sidra Shakil, M. Saleh Memon, P. S. Mahar, Abdul Fattah Memon, Muhammad Faisal Fahin, Seema N. Mumtaz, Sikandar Ali Sheikh. (2019) Visual Outcome of Vision Threatening Diabetic Retinopathy after Various Treatment Modalities, Pakistan Journal of Ophthalmology, Volume 35, Issue 1.
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