Abstract
Histological sections of both uninfected and naturally infected sheep liver with hydatidosis were studied.. Intensity of histopathological changes was found proportional to the size of cyst. Small cysts (1-2 mm diameter) showed pathological changes only close to the cyst wall. The hepatocytes were deformed due to reduced cytoplasmic contents and large gaps were seen around the fibrous cyst wall. Sinusoidal spaces were however expanded forming aster like channels around the cyst wall. Some of the hepatic cells were also found swollen. Medium (1 cm) and large (3-4 cm) cysts showed prominent changes near to the cyst wall, like pyknotic nuclei, heavy leucocytic infiltration and fibrosis. Hepatocytes also showed .cytoplasmic and nuclear vacuolation near the wall, of medium and large cysts. Some of the cysts also shoWed pressure atrophy, which was more common in larger cysts. Hepatic architecture was completely destroyed while prominent changes near the cyst wall included increase in sinusoidal spaces and bile canaliculi. Portal veins and lymphatics became indistinguishable. The histopathology of hepatocytes surrounding the cyst were noted at various distances from the cyst wall with the findings that the damage was inversely proportional to the distance from the cyst.
ZAHEER ANWAR , AKHTAR TANVEER , SHAHID BASHIR. (1999) ECHINOCOCCUS GRANULOSUS: HISTOPATHOLOGY OF NATURALLY INFECTED SHEEP LIVER, Punjab University Journal of Zoology, Volume 14, Issue 1.
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