Abstract
Background:Non-alcoholic Fatty Liver disease (NAFLD)is the most common cause of progressive liver disorders worldwide. Drug options are limited with varying results. Nigella sativain the form of herbal medicine could be another option because of its strong historical background.The objective of the study was to evaluate the effect Nigella sativaon various parameters in patients of NAFLD.Methods:A randomizedcontrolled trial wasconducted at outpatient clinic of medical unit-1 of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, inwhich seventy patients of NAFLD were divided in to interventional and non-interventionalgroups. The interventional group was given cap Nigella sativa1g twice a day while non-interventional group was given cap placebo in a same wayfor three months. Body weight, BMI,liver enzymes and ultrasound finding of fatty liver were assayed before and after treatment.Results:After 12 weeks treatment with Nigella sativabody weight decreased significantly from 86±13.8to76±12.6kg vs placebo (p=0.041).BMI also reduced significantly from 29.06±4.6 to 26.25±6.2kg/m2 vs placebo(p=0.012). There is remarkable reduction in aminotransferases level after treatment with Nigella sativavs placebo (ALT: 78.05±5.52 to 52.6±5.65 IU/L vs76.48±4.95–74.32±5.58 IU/L (p=0.036). AST: 65.54±4.56–44.56±5.52 IU/L vs 63.25±5.43–59.43±3.39 IU/L (p=0.021).There was overall 57.14 % patient had normal fatty liver grading on ultrasound after 12 weeks treatment with Nigella sativaas compared to placebo (p=0.002).Conclusion:Nigella sativaimproves bio chemical and fatty liver changes in NAFLD patients. Its use in early stages of NAFLD is recommended in order to prevent its life-threateningcomplication
Dr. Mazhar Hussain,, Ali Gul Tunio, , Lubna Akhtar, ,Ghulam Serwar Shaikh. (2017) EFFECTS OF NIGELLA SATIVAON VARIOUSPARAMETERS IN PATIENTS OF NON-ALCOHOLIC FATTY LIVER DISEAS, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 29, Issue 3.
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