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Abstract
Background:AtypicalHaemolyticUremicSyndrome(aHUS)isararelifethreateningentitycharacterizedbythrombocytopenia,haemolyticanaemiaandrenaldysfunction.Itisathromboticmicroangiopathyrelatedtogeneticmutationsinthealternatecomplementpathwayandhasadistinctpathophysiologywhichmakesithardertodistinguishfromothermicroangiopathies.Wepresentacaseofa25-year-oldmalepatientwithhistoryofpolysubstanceabusewhopresentedwithchestpainanddyspnoea.Headmittedtousinginjectableoxymorphone(Opana)twoweeksbeforepresentation.Patient’svitalsignswerestableexceptfortachycardiaandhighbloodpressure.Onphysicalexamination,epigastrictendernessandmildsplenomegalywasappreciated.UrineDrugScreenwaspositiveforoxycodoneandopiates.Laboratoryworkuprevealedhaemolyticanaemia,thrombocytopeniaandacutekidneyinjury.Extensiveevaluationresultedinourimpressionofthediseasebeingatypicalhaemolytic-uremicsyndrome.Hewasmanagedwithdialysis,intravenoussteroidsandplasmapheresiswithimprovementinhishematologicparameters.

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AmibhenGandhi,, SaadUllah,, ShaniKotadia, ,SamerNasser. (2017) OXYMORPHONEINDUCEDTHROMBOTICMICROANGIOPATHYMIMICKINGATYPICALHAEMOLYTICUREMICSYNDROME, , Volume 29, Issue 2.
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JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD
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Volume 29
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