Abstract
Objective: To ascertain the outcome of vitamin D3 supplementation on blood sugar fasting (BSF) of individuals with pre-diabetes and co-existing hypovitaminosis D3. Methodology: This quasi experimental study was carried out in the Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi from January to December 2019. Non-probability convenience sampling was done, and 140 individuals with pre-diabetes (BSF: 5.7 – 6.9 mmol/L) and coexisting hypovitaminosis D3 (< 50 nmol/L) were included in the study. Age wasbetween 21 to 60 years of either gender. They were randomly selected to receive 200,000 IU of cholecalciferol (vitamin D3 n = 70) or placebo (n = 70), in one dose at the commencement of study, and after one month. The outcome between BSF and vitamin D3 were comparedand analysed after 12 weeks by SPSS version 23. Results: The median of blood sugar fasting in the vitamin D3 group decreased from 5.4 to 5.1 and the interquartile range (IQR) decreased from 5.7 – 5.1 to 5.6 – 5.0 versus placebo (p = 0.001). Thus, there was a significant reduction in BSF in Vit. D3 group versus placebo. Conclusion: Vitamin D3 supplementation in individuals with pre-diabetes and co-existing hypovitaminosis D3 resulted in decrease in BSF and thus lowered the risk of progression to type 2 diabetes mellitus. Key words: Cholecalciferol, hypovitaminosis, placebo, pre-diabetes, supplementation.

Nausheen Ata, Mehwish Gilani, Qurrat-ul-Ain Haider, Muhammad Wasiullah Khan, Zainab Rahman. (2022) Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes, , Volume 47, Issue 2.
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