Abstract
Objective: To determine the correlation of vitamin- D
receptor protein (VDR) and vitamin-D with prediabetes.
Methodology: This case control study was conducted
at Diabetes and Endocrine clinic of Dow University
Hospital fromAugust to December 2019. It included
160 subjects (80 pre-diabetics, 80 controls with mean
age of 35.9 ± 10.43, 34.72 ± 12.10 years. The sample
size was estimated using open-epi software. Serum
vitamin D and VDR protein were determined using
sandwich enzyme immunoassay (ELISA). Multivariate regression analysis was done to evaluate the
independent predictors for pre-diabetes. Data were
analyzed on SPSS version 17.
Results: VDR protein (OR = 1.013, 95% CI = 1.024 –
1.041), IFG (OR = 0.992, 95% CI = 0.235 – 1.181),
IGT (OR = 0.911, 95% CI = 0.243 – 1.000) remained
the strong independent predictor of pre-diabetes in
logistic regression model adjusted for clinical and
anthropometric parameters.
Conclusion: Vitamin D and VDR could be used as a
screening marker and target for pre-diabetes. In the
future, this could be used for diabetes mellitus
prevention.
Keywords: Serum vitamin-D, prediabetes, VDR
gene.
