Abstract
Objective: To determine the correlation of vitamin- D receptor protein (VDR) and vitamin-D with prediabetes. Methodology: This case control study was conducted at Diabetes and Endocrine clinic of Dow University Hospital fromAugust to December 2019. It included 160 subjects (80 pre-diabetics, 80 controls with mean age of 35.9 ± 10.43, 34.72 ± 12.10 years. The sample size was estimated using open-epi software. Serum vitamin D and VDR protein were determined using sandwich enzyme immunoassay (ELISA). Multivariate regression analysis was done to evaluate the independent predictors for pre-diabetes. Data were analyzed on SPSS version 17. Results: VDR protein (OR = 1.013, 95% CI = 1.024 – 1.041), IFG (OR = 0.992, 95% CI = 0.235 – 1.181), IGT (OR = 0.911, 95% CI = 0.243 – 1.000) remained the strong independent predictor of pre-diabetes in logistic regression model adjusted for clinical and anthropometric parameters. Conclusion: Vitamin D and VDR could be used as a screening marker and target for pre-diabetes. In the future, this could be used for diabetes mellitus prevention. Keywords: Serum vitamin-D, prediabetes, VDR gene.

Ambreen Qamar, Mirza Saifulla Baig. (2022) Association of serum vitamin-D receptor protein levels with prediabetes in Pakistani population, , Volume 47, Issue 2.
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