Abstract
Vitiligo is an abnormal skin condition characterized by depigmentation of normal skin colour. It negatively
affects emotions, psychology, and self-esteem of a patient, especially conspicuous in the females who are more
conscious about their aesthetic appearance. It prevails equally in society affecting both sexes. Vitiligo has no
permanent cure. Psoralea corylifolia (PC) has been reported to yield significant positive outcomes in vitiligo
management. In current study, after approval from the ethical review board, a male patient (17 years old)
having vitiligo patches distributed on his skin symmetrically and having history of using solution of honey and
milk for facial partial pigmentation, was instructed to take half teaspoonful (equivalent to 05 grams) of
powdered seed of PC orally and to apply topically a cream containing hydroalcoholic extract (5% w/w) of the PC
seed regularly. The subject was naturally exposed to sunrays during his daily life activities. Liver and renal
functions were regularly (before treatment and 30 days thereafter) monitored to avoid any untoward effects of
oral therapy. Gradual pigmentation was recorded through photographs taken on regular basis. The selfcontrolled study design was followed. Local (topical cream) and systemic (oral powder from PC) therapy was
found to have an additive effect in complete restoration of the pigmentation of skin of the volunteer as
compared to self-controlled study design. Full facial pigmentation was obtained in six-month therapy. Liver and
renal functions remained undisturbed throughout the course of treatment. The powder form of P.C and its
extract incorporated in cream were found safe and efficacious for pigmentation of the vitiliginous skin.
Irshad Hussain, Hakim Ali Abro, Naem Mubarak. (2019) Skin Pigmentation Effects of Psoralea Corylifolia: A Case Study of Vitiligo, Journal of Islamic International Medical College, Volume-14, Issue-1.
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