Abstract
Objective: This study was designed to determine the relationship between maternal serum uric acid level at delivery in gestational hypertensive women and subsequent foetal outcome.
Methodology: A cross-sectional study involving 85 women with singleton pregnancy diagnosed with gestational hypertension and preeclampsia, admitted for delivery were recruited and normotensive pregnant women with singleton pregnancy served as control.
Results: Eighty five women had gestational hypertension or preeclampsia while the remaining 85 women were normotensives. Out of the 85 subjects with hypertensive disorder of pregnancy, 32 (37.6%) had gestational hypertension while 53 (62.4%) had preeclampsia. The mean age of the subjects was 31.02±6.02 years. The mean gestational age at delivery of the subjects was significantly lower than the controls. Forty seven (55.3%) of the subjects had hyperuricaemia (serum uric acid >339 µmol/L) whereas only 27.1% of the controls had elevated serum uric acid. The mean uric acid of the subjects was significantly higher than the normotensive controls (381.12±118.54µmol/L Vs 289.84±82.96µmol/L; p=0.002). The foetal outcomes were adversely affected among the hypertensive group compared to the normotensive arm.
Conclusion: There was adverse foetal outcome in the hypertensives in terms of preterm births, low birth-weight babies and neonatal ward admission. Gestational hypertension with hyperuricaemia was a predictor of poor foetal outcome but Apgar scores was not affected with the serum uric acid levels.
Adedayo A Oluwole, Olusoji Edward Jagun, Afolasade Olasimbo Oluwole, Olatubosun Oladipupo Olawale, Peter Oladipupo Adefuye, Mojisola Olumide Ayankunle. (2018) Comparative Evaluation of Maternal Serum Uric Acid Levels at Delivery Among Gestational Hypertensive Women and Its Effect on Foetal Outcome in Sagamu, Nigeria, Journal of the Society of Obstetrics and Gynaecologists of Pakistan , Volume-08, Issue-3.
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